Jaakko Malmivuo: Bioelectromagnetism
Recorded at the Ragnar Granit Institute, Autumn 2006.
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Lecture 1 | |
![]() | Bioelectromagnetism, Main topics, Textbook, Interdisciplinary sciences |
![]() | Bioelectromagnetism, Subdivisions of bioelectromagnetism |
![]() | Bioelectric phenomena, Generation of bioelectric signals, Importance of bioelectromagnetism, Funny example |
![]() | History of bioelectromagnetism, William Gilbert, Jan Swammerdam, Luigi Galvani, Electrotherapy |
![]() | Hans Christian Ørstedt, Hans Berger - EEG, Magnetocardiogram, Hermann Helmholtz, Nernst equation |
Lecture 2 | |
![]() | Anatomical basis of bioelectromagnetism, Nerve and muscle cell, Cell membrane, Motoneuron |
![]() | Synapse, Striated muscle, Bioelectric function, Response of the membrane potential, Conduction of nerve impulse |
![]() | Subthreshold membrane phenomena, Nernst equation, Electric potential and field, Nernst-Planc equation, Illustration |
![]() | The origin of resting voltage, Electric circuit of membrane, Goldman-Hodgkin-Katz equation, Reversal voltage, Transmembrane ion flux |
Lecture 3 | |
![]() | Subthreshold membrane phenomena, Nernst equation, Goldman-Hodgkin-Katz equation, Transmembrane ion flux |
![]() | Cable equation of the axon, Steady state response, Stimulation with step-current, Strength-duration relation |
![]() | Active behavior of the membrane, Voltage clamp method, Space clamp, Voltage clamp |
![]() | Voltage clamp, Examples, Transmembrane ion flux, Preparation of an axon, Fugu fish |
![]() | Hodgin-Huxley model, Parallel conductance model, Voltage clamp experiments, Model for potassium conductance |
Lecture 4 | |
![]() | Hodgkin-Huxley model, Parallel conductance model, Potassium conductance, Model for potassium conductance |
![]() | Sodium conductance, Model for sodium conductance, A model for channel gating |
![]() | Hodgin-Huxley equations, Sodium and potassium conductances, Propagating nerve impulse |
![]() | Patch clamp method, Current through a single ion channel, Modern understanding of the ionic channels |
![]() | Synapses, receptor cells and brain, Excitatory and inhibitory synapses, Spatial and temporal summation, Electric model of the synapse |
Lecture 5 | |
![]() | Model for potassium and sodium conductances, Nobel Prize 1991, Patch clamp method |
![]() | Synapses, receptor cells and brain, Reflex arch, Division of sensory and motoric functions, Cranial nerves |
![]() | The heart, Anatomy and physiology of the heart, Cross-section video, Striated muscle, Syncytium |
![]() | Cardiac cycle, Generation of bioelectric signal, Conduction system, Intrinsic frequency, Electrophysiology of the heart |
![]() | Total excitation of the isolated human heart, Genesis of the electrocardiogram |
Lecture 6 | |
![]() | Volume source and volume conductor |
![]() | Bioelectric source and its electric field |
![]() | Volume source in a homogeneous volume conductor |
![]() | The concept of modeling |
![]() | The human body as a volume conductor |
![]() | Forward and inverse problems |
Lecture 7 | |
![]() | Volume source, Piecewise homogeneous volume conductor, Green's theorem, Dipole |
![]() | Theoretical methods, Solid angle theorem, Double layer, Inhomogeneous double layer, Double layer sources |
![]() | Lead Vector, Ohm's Law, lead vector concept, Lead voltage between two measurement points |
![]() | Einthoven triangle, Burger Model, Variation of the Frank model |
![]() | Lead vector, Image surface, Points inside the image surface, Design of orthonormal lead systems |
Lecture 8 | |
![]() | Solid angle theorem, Double layer source, Lead vector |
![]() | Image surface, Design of orthonormal lead systems |
![]() | Lead field, Sensitivity distribution, Linearity, Superposition |
![]() | Reciprocity, Hermann von Helmholtz, Historical approach, Electric lead |
![]() | Ideal lead field, Effect of electrode configuration, Synthesizing an ideal lead field |
Lecture 9 | |
![]() | Review of lead field concept, Sensitivity distribution, Reciprocity and electric lead |
![]() | Gabor-Nelson theorem, Summary of the theoretical methods |
![]() | Biomagnetism, Equations, Biomagnetic fields |
![]() | Reciprocity theorem for magnetic fields, Equations for electric and magnetic leads |
![]() | Magnetic dipole moment, Ideal lead field, Synthesization of ideal magnetic lead, Radial and tangential sensitivities |
Lecture 10 | |
![]() | Reciprocity theorem for magnetic fields, Biomagnetic fields repeated |
![]() | Magnetic dipole moment, Special properties of magnetic lead fields |
![]() | Sensitivity distribution of basic magnetic leads, Magnetometers |
![]() | Independence of bioelectric and biomagnetic fields, Helmholtz theorem |
![]() | Electroencephalograpy, EEG lead systems, Behavior of EEG signal |
![]() | Magnetoencephalography, History, Sensitivity distribution, Axial and planar gradiometers |
![]() | Comparison of EEG and MEG half sensitivity, Electrode in the source region |
![]() | Effect of skull resistivity, Summary. |
Lecture 11 | |
![]() | 12-lead ECG system, Waller, Einthoven |
![]() | ECG Signal |
![]() | Wilson central terminal, Goldberger leads, Precordial leads |
![]() | Modifications of the 12-lead system, The information content of the 12 lead system |
Lecture 12 | |
![]() | VCG Lead systems, Uncorrected VCG lead systems |
![]() | Corrected VCG Systems, Frank lead system |
Lecture 13 | |
![]() | Frank lead system repeated |
![]() | Lead systems: McFee-Parungao, SVEC III, Gabor-Nelson |
![]() | Discussion on VCG leads |
![]() | Other lead systems, Moving dipole, Multiple-dipole model, Multipole, Clinical diagnosis |
![]() | Summary of models used |
![]() | Distortion factors in ECG, Effect of the inhomogeneities, Brody effect |
Lecture 14 | |
![]() | Brody effect, Direction of ventricular activation, Effect of blood resistivity |
![]() | The basis of ECG diagnosis, The application areas of ECG diagnosis, Electric axis of the heart, Ventricular arrhythmias |
![]() | Disorders in the activation sequence, Myocardial ischemia and infarction |
![]() | Magnetocardiography, History, Standard grid |
Lecture 15 | |
![]() | Magnetocardiography, Methods for detecting magnetic heart vector, McFee lead system, XYZ-lead system, ABC-lead system |
![]() | Sensitrivity distribution, Generation of MCG signal |
![]() | Clinical applications: Fetal MCG, DC-MCG |
![]() | General solution for the clinical application, Theoretical aspects, Helmholz's theorem |
![]() | The electromagnetocardiography method (EMCG), Clinical study, Results |
Lecture 16 | |
![]() | Electric and magnetic stimulation, History, Applications, Taser |
![]() | Magnetic stimulation, History, Principle of magnetic stimulation, Distribution of stimulation current, Electric and magnetic stimulation of the heart, Pacemakers |
![]() | Cardiac defibrillation, Mechanism, Defibrillator devices |
![]() | Measurement of the intrinsic electric properties of biological tissues, Impedance cardiography, Signals, Origin of the impedance signal |
Lecture 17 | |
![]() | Impedance cardiography, Signals, Origin of the signal |
![]() | Accuracy of the impedance cardiography, Other applications of impedance pletysmography |
![]() | Impedance tomography, Measurement methods, Image reconstruction |
![]() | Electrodermal response, Lie detector, EOG, Electroretinogram |
Lecture 18 | |
![]() | Objectives, Discipline bioelectromagnetism |
![]() | Subthreshold membrane phenomena, Nerst equation, Origin of the resting voltage |
![]() | Active behavior of the membrane, Voltage clamp, Results |
![]() | Bioelectric sources and conductors, Models |
Lecture 19 | |
![]() | Theoretical methods in bioelectromagnetism, Solid angle theorem, Image surface, Linearity, Superposition, Electric lead |