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I | Introduction
Course Content
Why Use Optical Methods?
Why Should You Learn Biomedical Optics?
Fundamentals of Optics
Overview of Spectroscopy
Classical Description of Light
Light-Tissue Interaction
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II | Basic Optics
What is Light
Short Wavelengths
Radiation Power
Radiation Energy
Radiation Intensity
Collection of Light
Integrating Spheres
Detector
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III | Tissue Optical Properties
Optical Properties vs Optical Measurements
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Absorption
Scattering
Anisotropy
Isotropic Scattering
Anisotropic Values
Summary
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Scattering Cases
Rayleight Scattering
Mie Theory Model
Summary Optical Properties
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IV | Optical Transport in Tissues
Primary Unscattered Light
Demonstration
Optical Fiber in Scattering Medium
Irradiance
1D Model
Fluence Rate
Time-Resolved and Steady-State Fluence Rate
Light Diffusion
Internal Source and Virtual Source
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V | Transport Equation
The Dualism of Light
Light Propagation in Random Medium
Transport Equation
Monte Carlo Simulations
Radiance L
The Transport Equation
Energy Conservation
The Total Attenuation Coefficient and Albedo
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VI | Diffusion Equation
Approximations
Spherical Harmonics
Diffusion
Photon Density Function
Photon current Density
Mathematical Simplifications
The Diffusion Coefficient
The Diffusion Equation
Point Source Solution
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| Light Scattering in Tissue by Monte Carlo Simulation
What is Monte Carlo Modeling?
Program Menu and Steps
End of Monte Carlo Model
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VII | Optical Properties Measurements
Attenuation of Collimated Beam
Collimated Transmission Calculations
Total Diffuse Reflectance
Optical Penetration Depth
Total Diffuse Reflectance
Calculations
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Integrating Sphere
Reflection Calculations
Goniometer Principle
Scattering Pattern
CCD Camera with Tilted Source
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VIII | Devices and Protocols
Optical Fiber Bundle
Measurement Situation
Multifiber Probe
Oxygenation and Blood Content
Fluorescence
PDT
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| Polarization
Amplitude Scattering Matrix
Degree of Polarization
Scattering Matrix
System Setup
Polarization Image
Prerequisites
Degree of Polarization
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| QUELS
Evolution
Theory Principle
Anisotropy
Scattering Function
Detection Model
Coherence Area
Photocurrent
16 Terms of E-Fields
Light Beat Detection
The Doppler Component
Wiener –Khintchine Theorem
Perfusion Value
Sampling Volume
LDPM
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| Optical Coherence Tomography
Imaging Methods in Tissue
Optical Coherence Tomography
Temporal Coherence
Coherence Properties
Correlation Functions
Photon Sources
Coherence
Coherence Length
Optical Coherence Tomography
Lightsource Parameters
Optical Coherence Tomography
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